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Protoanemonin

In vitro / Animal
Lactone

Mechanism of Action

Potent vesicant and irritant; responsible for counter-irritant and toxic effects; destroyed by drying
Toxic vesicant present in fresh plant only; destroyed by drying. Responsible for fresh-plant toxicity.
Vesicant (causes blistering); antimicrobial; toxic — converts to anemonin on drying

Research Notes

ButtercupWestern

Potent vesicant responsible for both therapeutic rubefacient activity and toxicity. Destroyed by drying.

Lesser CelandineWestern

Toxic vesicant destroyed by drying; responsible for the contraindication against fresh-plant internal use.

PulsatillaWestern

Potent skin irritant and vesicant in fresh plant; antimicrobial activity; decomposes to less toxic anemonin upon drying

Found In 3 Herbs

Buttercup

Buttercup

Western
Lesser Celandine

Lesser Celandine

Western
Pulsatilla

Pulsatilla

Western

3D Molecular Structure

Lactone
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Protoanemonin

LactoneCyclic esters with diverse pharmacological activities

Representative pattern: C₂₁H₃₀O₂

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

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