Proflamin

Animal

Mechanism of Action

Proflamin is an acidic glycoprotein (molecular weight approximately 13,000) that demonstrates antitumor activity through enhancement of host immune response rather than direct cytotoxicity. It activates peritoneal macrophages, increasing their tumoricidal activity through NO and reactive oxygen species production. Proflamin also stimulates splenocyte proliferation and enhances NK cell activity against tumor target cells.

Research Notes

Enoki (Medicinal)Mushroom

Ikekawa et al. (1982) demonstrated that proflamin inhibited the growth of Sarcoma 180 in mice with tumor inhibition rates exceeding 80%. Further work showed that the antitumor effect was host-mediated, as proflamin was inactive against tumor cells in vitro but highly effective in immunocompetent animals. Macrophage activation and NK cell enhancement were confirmed as primary mechanisms. Evidence is preclinical.

Found In 1 Herb

Enoki (Medicinal)

Mushroom

3D Molecular Structure

Glycoprotein

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Proflamin

GlycoproteinBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.