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Proflamin
AnimalMechanism of Action
Proflamin is an acidic glycoprotein (molecular weight approximately 13,000) that demonstrates antitumor activity through enhancement of host immune response rather than direct cytotoxicity. It activates peritoneal macrophages, increasing their tumoricidal activity through NO and reactive oxygen species production. Proflamin also stimulates splenocyte proliferation and enhances NK cell activity against tumor target cells.
Research Notes
Enoki (Medicinal)Mushroom
Ikekawa et al. (1982) demonstrated that proflamin inhibited the growth of Sarcoma 180 in mice with tumor inhibition rates exceeding 80%. Further work showed that the antitumor effect was host-mediated, as proflamin was inactive against tumor cells in vitro but highly effective in immunocompetent animals. Macrophage activation and NK cell enhancement were confirmed as primary mechanisms. Evidence is preclinical.
Found In 1 Herb
3D Molecular Structure
Glycoprotein
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Proflamin
GlycoproteinBioactive phytochemical with therapeutic properties
Representative pattern: C₄H₂NO
Atoms
Carbon
Oxygen
Nitrogen
Hydrogen
Live Research
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