Pristimerin

In vitro / Animal

Quinone methide triterpenoid (friedelane-type)

Mechanism of Action

Potent proteasome inhibitor and NF-κB pathway suppressor; induces apoptosis in cancer cell lines via caspase-3/7 activation and Bcl-2/Bax ratio modulation; inhibits angiogenesis via VEGF-receptor downregulation; anti-inflammatory through IKK-β kinase inhibition upstream of NF-κB nuclear translocation.

Research Notes

ChuchuhuasiSouth American

Pristimerin is the most pharmacologically characterised compound in Maytenus macrocarpa and related Celastraceae. Consistent antiproliferative activity has been demonstrated across numerous cancer cell lines including prostate, breast, leukaemia, and colon models. Anti-inflammatory efficacy in rodent models of arthritis and colitis corroborates the traditional anti-rheumatic use. No human clinical trials of isolated pristimerin exist; bioavailability and in vivo pharmacokinetics require further characterisation.

Found In 1 Herb

Chuchuhuasi

South American

3D Molecular Structure

Quinone methide triterpenoid (friedelane-type)

Drag to rotate · Click atoms to explore

Pristimerin

Quinone methide triterpenoid (friedelane-type)Modified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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