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Polysaccharides (P. baumii fraction)

Moderate
Polysaccharide (beta-glucan and heteropolysaccharide)

Mechanism of Action

Activate innate and adaptive immunity by promoting proliferation of splenic T and B lymphocytes, enhancing peritoneal and splenic NK cell cytotoxicity, and stimulating cytokine secretion. In immunosuppressed models, P. baumii polysaccharides ameliorate cyclophosphamide-induced myelosuppression by supporting bone marrow cell recovery, normalizing hematological markers, and restoring T-lymphocyte numbers. Inhibit tumor growth and metastasis through direct cytotoxicity and immune-mediated anti-tumor surveillance.

Research Notes

Black Hoof MushroomMushroom

Administration of P. baumii ethanol extract to cyclophosphamide-immunosuppressed mice significantly enhanced T- and B-lymphocyte proliferation, NK cell activity, bone marrow cell counts, and cytokine levels (Nutrition Research, 2020). Water-soluble polysaccharides showed immunostimulatory activity on splenic lymphocyte proliferation and macrophage activation in vitro. Polysaccharide fractions demonstrated tumor growth inhibition in multiple preclinical cancer models including hepatocellular carcinoma and colon cancer.

Found In 1 Herb

Black Hoof Mushroom

Black Hoof Mushroom

Mushroom

3D Molecular Structure

Polysaccharide (beta-glucan and heteropolysaccharide)
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Polysaccharides (P. baumii fraction)

Polysaccharide (beta-glucan and heteropolysaccharide)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.