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Polysaccharides (P. baumii fraction)
ModerateMechanism of Action
Activate innate and adaptive immunity by promoting proliferation of splenic T and B lymphocytes, enhancing peritoneal and splenic NK cell cytotoxicity, and stimulating cytokine secretion. In immunosuppressed models, P. baumii polysaccharides ameliorate cyclophosphamide-induced myelosuppression by supporting bone marrow cell recovery, normalizing hematological markers, and restoring T-lymphocyte numbers. Inhibit tumor growth and metastasis through direct cytotoxicity and immune-mediated anti-tumor surveillance.
Research Notes
Black Hoof MushroomMushroom
Administration of P. baumii ethanol extract to cyclophosphamide-immunosuppressed mice significantly enhanced T- and B-lymphocyte proliferation, NK cell activity, bone marrow cell counts, and cytokine levels (Nutrition Research, 2020). Water-soluble polysaccharides showed immunostimulatory activity on splenic lymphocyte proliferation and macrophage activation in vitro. Polysaccharide fractions demonstrated tumor growth inhibition in multiple preclinical cancer models including hepatocellular carcinoma and colon cancer.
Found In 1 Herb
3D Molecular Structure
Polysaccharide (beta-glucan and heteropolysaccharide)
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Polysaccharides (P. baumii fraction)
Polysaccharide (beta-glucan and heteropolysaccharide)Complex carbohydrate polymers that modulate immune response
Representative pattern: (C₆H₁₀O₅)ₙ
Atoms
Carbon
Oxygen
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