Polysaccharides (JCH-1, JCH-2)

Moderate

Heteropolysaccharide (mannose-glucose-galactose)

Mechanism of Action

Heteropolysaccharides composed of mannose, glucose, and galactose in variable ratios activate macrophages through TLR-2 and TLR-4 pattern recognition receptors. Downstream NF-κB and MAPK signaling promotes cytokine synthesis (IL-1β, IL-6, TNF-α) and enhances phagocytic activity. Antioxidant activity involves direct free radical scavenging and upregulation of endogenous antioxidant enzymes (SOD, CAT, GSH-Px). Anti-aging effects are mediated through mitochondrial protection and telomere maintenance pathways.

Research Notes

Cicada FlowerMushroom

Two heteropolysaccharides (JCH-1 and JCH-2) with different molecular weights were isolated and characterized from I. cicadae. In vitro studies confirmed immunomodulatory activity including macrophage activation and cytokine production. Polysaccharide fractions demonstrated significant antioxidant and anti-aging activities in cell culture models, with potential as dietary supplements to slow aging. Animal studies show protective effects against cisplatin-induced acute kidney injury through TLR4/NF-κB/MAPK pathway suppression and HO-1/Nrf2 activation.

Found In 1 Herb

Cicada Flower

Mushroom

3D Molecular Structure

Heteropolysaccharide (mannose-glucose-galactose)

Drag to rotate · Click atoms to explore

Polysaccharides (JCH-1, JCH-2)

Heteropolysaccharide (mannose-glucose-galactose)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.