Polysaccharides (high-molecular-weight)

Moderate

Mechanism of Action

Activate macrophage and natural killer (NK) cell function via pattern recognition receptor (PRR) engagement; induce release of interferon-γ and IL-12 from dendritic cells; enhance phagocytic activity of alveolar macrophages; stimulate ciliary beat frequency of bronchial epithelial cells, improving mucociliary clearance.

Research Notes

Pelargonium sidoidesAfrican

Polysaccharide fractions of Pelargonium root extracts demonstrate dose-dependent macrophage activation and NK cell cytotoxicity enhancement in vitro. In vivo mouse infection models show improved survival rates from bacterial pneumonia with polysaccharide pre-treatment. Mucociliary stimulation has been confirmed in human bronchial epithelial cell assays and may partially explain clinical improvement in productive cough.

Found In 1 Herb

Pelargonium sidoides

African

3D Molecular Structure

Immunomodulatory polysaccharides

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Polysaccharides (high-molecular-weight)

Immunomodulatory polysaccharidesComplex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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