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Polysaccharides (CS-F10, CS-F30)
In vitro / AnimalMechanism of Action
CS-F10 and CS-F30 are heteropolysaccharides with galactomannan backbones and glucose/mannose branches. They activate macrophages via TLR-4 and Dectin-1 receptors, stimulating NO production, phagocytic activity, and pro-inflammatory cytokine release (TNF-α, IL-1β, IL-6). At higher concentrations, they shift toward anti-inflammatory IL-10 production, demonstrating biphasic immunomodulation rather than simple immunostimulation.
Research Notes
Wang et al. (2012) characterized the structure and immunomodulatory activity of CS polysaccharides, demonstrating dose-dependent macrophage activation in RAW 264.7 cells. Li et al. (2011) showed that O. sinensis polysaccharides enhanced splenocyte proliferation and NK cell activity in tumor-bearing mice. Cs-4 mycelium polysaccharides showed comparable immunomodulatory activity to wild specimen polysaccharides in several comparative studies. The biphasic immunomodulatory profile distinguishes O. sinensis from more purely immunostimulatory mushrooms like Turkey Tail.
Found In 1 Herb
3D Molecular Structure
Galactomannan and glucan polysaccharides
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Polysaccharides (CS-F10, CS-F30)
Galactomannan and glucan polysaccharidesComplex carbohydrate polymers that modulate immune response
Representative pattern: (C₆H₁₀O₅)ₙ
Atoms
Carbon
Oxygen
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