Polyporusterone A

Preliminary

Mechanism of Action

Inhibits proliferation of leukemia L1210 cells in a concentration-dependent manner through cell-cycle arrest and apoptosis induction. The polyporusterone series (A–G) share the ergostane skeleton but differ in oxygenation pattern, contributing to varying potencies against different cancer cell lines including liver cancer (Hep3B) and colon cancer (HT-29).

Research Notes

Zhu LingTCM

Polyporusterones A–G were isolated from P. umbellatus sclerotium and tested against leukemia L1210 cells, demonstrating concentration-dependent anti-proliferative activity. Additional cytotoxicity was confirmed against Hep3B (hepatocellular carcinoma) and HT-29 (colon adenocarcinoma) cell lines. All studies remain at the in vitro level; no human clinical data on isolated polyporusterones are available.

Found In 1 Herb

Zhu Ling

TCM

3D Molecular Structure

Ergostane-type steroid

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Polyporusterone A

Ergostane-type steroidLipid-based molecules that regulate physiological processes

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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