Polyphenols and flavonoids

Preliminary

Mechanism of Action

Polyphenolic compounds scavenge free radicals through hydrogen atom transfer and single electron transfer mechanisms, chelate pro-oxidant transition metals (Fe²⁺, Cu²⁺), and upregulate endogenous antioxidant enzyme expression through Nrf2/ARE (antioxidant response element) pathway activation. Flavonoid components modulate inflammatory signaling by inhibiting COX-2 and iNOS enzyme expression and suppressing NF-κB nuclear translocation.

Research Notes

Golden EarMushroom

Fermented N. aurantialba preparations showed DPPH radical scavenging capacity of 94.75% compared to 50.88% in unfermented preparations, indicating that fermentation significantly enhances polyphenol bioavailability and antioxidant activity. Oil-based cooking methods were shown to enhance phenolic compound extraction efficiency. Studies are primarily in vitro; clinical antioxidant data in human subjects is lacking.

Found In 1 Herb

Golden Ear

Mushroom

3D Molecular Structure

Phenolic compounds

Drag to rotate · Click atoms to explore

Polyphenols and flavonoids

Phenolic compoundsSimple aromatic compounds with antimicrobial properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Phenolic compounds)

Polyphenols(2)Polyphenols and tannins(1)

Live Research

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