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Plumbagin

Clinical trial
Naphthoquinone

Mechanism of Action

Inhibits NF-κB signaling by preventing phosphorylation of IκBα; inhibits STAT3 activation; induces ROS-mediated apoptosis through mitochondrial dysfunction
NF-κB inhibition; ROS generation in cancer cells; anti-inflammatory
Primary antitussive and antispasmodic constituent; also exhibits antimicrobial and cytotoxic activity on bronchial smooth muscle

Research Notes

Black WalnutWestern

Preclinical studies demonstrate anticancer activity against multiple cell lines. In vitro antifungal MIC values of 1.56–12.5 µg/mL against dermatophytes and Candida species. Antiparasitic activity against Leishmania donovani documented.

ChitrakAyurvedic

Potent anticancer activity in vitro; narrow therapeutic window

SundewWestern

Plumbagin is the primary active naphthoquinone with demonstrated antitussive, antispasmodic, and antimicrobial activity. Supports Commission E approval for cough.

Found In 3 Herbs

Black Walnut

Black Walnut

Western
Chitrak

Chitrak

Ayurvedic
Sundew

Sundew

Western

3D Molecular Structure

Naphthoquinone
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Plumbagin

NaphthoquinoneBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms
Carbon
Oxygen
Nitrogen
Hydrogen

Related Compounds (Naphthoquinone)

Alkannin(1)Beta-lapachone(1)Juglone(1)Lapachol(1)Lapachol and naphthoquinone derivatives(1)Ramentaceone(1)Shikonin(2)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.