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Phelligridins A-J

In vitro
Polymerized styrylpyrones (furanone derivatives)

Mechanism of Action

Phelligridins are a family of structurally diverse polymerized styrylpyrones unique to Phellinus/Inonotus species. These compounds exhibit multi-target antioxidant activity through a combination of direct radical scavenging (particularly against DPPH, ABTS, and superoxide radicals), metal ion chelation (Fe2+ and Cu2+), and inhibition of lipid peroxidation in biological membranes. Several phelligridins also demonstrate anti-inflammatory activity through suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in activated macrophages, and antiproliferative effects against tumor cell lines through mechanisms involving cell cycle arrest and mitochondrial-mediated apoptosis.

Research Notes

Sang HuangMushroom

Phelligridins A through J were originally isolated and characterized from P. igniarius and P. baumii fruiting bodies by multiple research groups in China and Korea. Antioxidant activity studies demonstrated that several phelligridins possessed stronger free radical scavenging capacity than the reference antioxidant vitamin E. In vitro cytotoxicity screening revealed selective activity against certain cancer cell lines with relatively lower toxicity to normal cells. The structural diversity of the phelligridin family — ranging from dimeric to trimeric styrylpyrone oligomers — has made them targets for structure-activity relationship studies.

Found In 1 Herb

Sang Huang

Sang Huang

Mushroom

3D Molecular Structure

Polymerized styrylpyrones (furanone derivatives)
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Phelligridins A-J

Polymerized styrylpyrones (furanone derivatives)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms
Carbon
Oxygen
Nitrogen
Hydrogen

Live Research

Open on PubMed

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