Petroselinic Acid

Preliminary

Mechanism of Action

Inhibitor of arachidonic acid conversion to pro-inflammatory eicosanoids through competitive displacement in phospholipid membranes; reduces 5-LOX activity by altering membrane lipid composition and fluidity; inhibits conversion of linoleic acid to arachidonic acid via Δ6-desaturase inhibition; antimicrobial properties against Gram-positive bacteria through membrane fluidity alteration.

Research Notes

Coriander SeedWestern

Petroselinic acid is found at uniquely high concentrations in coriander (50-90% of fixed oil) compared to all other common foods. In vitro and animal studies confirm anti-inflammatory activity through multiple arachidonic acid pathway interactions. The compound's distinct n-12 positional geometry compared to common oleic acid (n-9) confers unique enzymatic interactions. Human clinical data as an isolated compound is very limited; mechanistic evidence is primarily from in vitro lipid biology studies.

Found In 1 Herb

Coriander Seed

Western

3D Molecular Structure

Monounsaturated fatty acid (C18:1 n-12)

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Petroselinic Acid

Monounsaturated fatty acid (C18:1 n-12)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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