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Parthenolide
Clinical trialMechanism of Action
Inhibits NF-κB nuclear translocation; suppresses TNF-α, IL-6, IL-8; reduces leukotriene and prostaglandin synthesis
Parthenolide inhibits NF-κB activation by alkylating cysteine residues on the IKKbeta subunit and p65 (RelA), preventing nuclear translocation and pro-inflammatory gene transcription. It also depletes glutathione in parasitic organisms, contributing to oxidative stress-mediated vermicidal activity. Additionally, parthenolide inhibits STAT3 phosphorylation and sensitizes cells to apoptosis.
Research Notes
FeverfewWestern
Parthenolide is the primary bioactive in feverfew, with clinical evidence for migraine prophylaxis and inflammatory conditions. Demonstrates broad anti-inflammatory action through NF-κB pathway inhibition, relevant for musculoskeletal pain management.
TansyWestern
Parthenolide is the primary bioactive sesquiterpene lactone in the closely related feverfew (Tanacetum parthenium), where it has been validated in multiple RCTs for migraine prophylaxis. In tansy, parthenolide content is variable (0.01–0.5% depending on chemotype). In vitro studies show potent NF-κB inhibition with IC50 ~1 µM and selective cytotoxicity against leukemia stem cells (Guzman et al., 2005, Blood).
Found In 2 Herbs
3D Molecular Structure
Sesquiterpene lactone (α,β-unsaturated γ-lactone with exocyclic methylene)
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Parthenolide
Sesquiterpene lactone (α,β-unsaturated γ-lactone with exocyclic methylene)Aromatic plant metabolites with anti-inflammatory properties
Representative pattern: C₂₁H₃₀O₂
Atoms
Carbon
Oxygen
Live Research
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