AlertsSign in
Back to Compound Explorer

Parthenolide

Clinical trial
Sesquiterpene lactone (α,β-unsaturated γ-lactone with exocyclic methylene)

Mechanism of Action

Inhibits NF-κB nuclear translocation; suppresses TNF-α, IL-6, IL-8; reduces leukotriene and prostaglandin synthesis
Parthenolide inhibits NF-κB activation by alkylating cysteine residues on the IKKbeta subunit and p65 (RelA), preventing nuclear translocation and pro-inflammatory gene transcription. It also depletes glutathione in parasitic organisms, contributing to oxidative stress-mediated vermicidal activity. Additionally, parthenolide inhibits STAT3 phosphorylation and sensitizes cells to apoptosis.

Research Notes

FeverfewWestern

Parthenolide is the primary bioactive in feverfew, with clinical evidence for migraine prophylaxis and inflammatory conditions. Demonstrates broad anti-inflammatory action through NF-κB pathway inhibition, relevant for musculoskeletal pain management.

TansyWestern

Parthenolide is the primary bioactive sesquiterpene lactone in the closely related feverfew (Tanacetum parthenium), where it has been validated in multiple RCTs for migraine prophylaxis. In tansy, parthenolide content is variable (0.01–0.5% depending on chemotype). In vitro studies show potent NF-κB inhibition with IC50 ~1 µM and selective cytotoxicity against leukemia stem cells (Guzman et al., 2005, Blood).

Found In 2 Herbs

Feverfew

Feverfew

Western
Tansy

Tansy

Western

3D Molecular Structure

Sesquiterpene lactone (α,β-unsaturated γ-lactone with exocyclic methylene)
Drag to rotate · Click atoms to explore

Parthenolide

Sesquiterpene lactone (α,β-unsaturated γ-lactone with exocyclic methylene)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₂₁H₃₀O₂

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.