Paeoniflorin

Clinical trial

Mechanism of Action

GABA-A receptor modulation; mu-opioid receptor agonism; stress hormone regulation

Anti-inflammatory via NF-kB inhibition, antiplatelet, immunomodulatory (Th1/Th2 balance), antispasmodic, hepatoprotective

Anti-inflammatory via NF-kB inhibition, analgesic, hepatoprotective, immunomodulatory, antispasmodic

Research Notes

Peony (Western)Western

Paeoniflorin enhances GABAergic and opioidergic signaling, reducing cortisol and promoting relaxation. Clinical trials in women show benefits for PMS, dysmenorrhea, and stress-related hormonal disruption at 1-3g daily dosing.

Red Peony (Chi Shao)TCM

Hepatoprotective in chronic hepatitis models. Anti-inflammatory in rheumatoid arthritis models. TGP (Total Glucosides of Paeony) is approved prescription drug in China for RA.

White Peony (Bai Shao)TCM

Reduced inflammation markers in RA models. Hepatoprotective in CCl4-induced liver injury. Modulated Th1/Th2 balance in autoimmune models.

Found In 3 Herbs

3D Molecular Structure

Monoterpene glycoside

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Paeoniflorin

Monoterpene glycosideAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Related Compounds (Monoterpene glycoside)

Albiflorin(1)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.