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Paeoniflorin
Clinical trialMechanism of Action
GABA-A receptor modulation; mu-opioid receptor agonism; stress hormone regulation
Anti-inflammatory via NF-kB inhibition, antiplatelet, immunomodulatory (Th1/Th2 balance), antispasmodic, hepatoprotective
Anti-inflammatory via NF-kB inhibition, analgesic, hepatoprotective, immunomodulatory, antispasmodic
Research Notes
Peony (Western)Western
Paeoniflorin enhances GABAergic and opioidergic signaling, reducing cortisol and promoting relaxation. Clinical trials in women show benefits for PMS, dysmenorrhea, and stress-related hormonal disruption at 1-3g daily dosing.
Hepatoprotective in chronic hepatitis models. Anti-inflammatory in rheumatoid arthritis models. TGP (Total Glucosides of Paeony) is approved prescription drug in China for RA.
Reduced inflammation markers in RA models. Hepatoprotective in CCl4-induced liver injury. Modulated Th1/Th2 balance in autoimmune models.
Found In 3 Herbs
3D Molecular Structure
Monoterpene glycoside
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Paeoniflorin
Monoterpene glycosideAromatic plant metabolites with anti-inflammatory properties
Representative pattern: C₁₁H₁₄O₆
Atoms
Carbon
Oxygen
Related Compounds (Monoterpene glycoside)
Live Research
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