p-Cymene

In vitro

Mechanism of Action

Antimicrobial, anti-inflammatory

p-Cymene acts as a membrane-active antimicrobial by inserting into bacterial lipid bilayers, increasing membrane fluidity and permeability, leading to leakage of intracellular contents and dissipation of the proton motive force. It also exhibits anti-inflammatory activity by inhibiting neutrophil migration through suppression of LTB4 and IL-1beta production, and demonstrates analgesic effects via modulation of opioidergic and vanilloid (TRPV1) pathways.

Research Notes

Black Seed / NigellaWestern

Largely preclinical research

EpazoteSouth American

Antimicrobial activity of p-cymene has been demonstrated against a broad spectrum of bacteria and fungi, though it is generally considered a modulator that enhances the activity of co-occurring compounds (carvacrol, thymol) rather than a potent standalone antimicrobial (Marchese et al., 2017). Anti-inflammatory activity in carrageenan-induced peritonitis models shows significant reduction in neutrophil infiltration. Analgesic effects in mouse writhing and hot plate tests have been reported with ED50 values comparable to low-dose NSAIDs.

Found In 2 Herbs

Black Seed / Nigella

Western

Epazote

South American

3D Molecular Structure

Monoterpene

Drag to rotate · Click atoms to explore

p-Cymene

MonoterpeneAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Monoterpene)

Limonene(3)Myrcene(2)Sabinene(1)β-Phellandrene(1)

Live Research

Open on PubMed

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