Officinalic acid

In vitro

Lanostane triterpenoid (Agarikon-specific)

Mechanism of Action

A structurally unique lanostane-type triterpenoid identified specifically from Fomitopsis officinalis with inhibitory activity against influenza A (H1N1) viral replication in ex vivo assays; precise molecular target has not been fully characterised, though viral RNA polymerase inhibition has been proposed as a mechanism based on structural modelling studies.

Research Notes

AgarikonMushroom

Officinalic acid represents one of the chemotaxonomically distinctive compounds of Fomitopsis officinalis relative to related Fomitopsis species. It was identified in bioactivity-guided fractionation studies of Agarikon extracts for antiviral properties. Preliminary antiviral data are from ex vivo cell culture models only; no in vivo or clinical data are available. Its status as a potential novel antiviral scaffold has attracted limited but growing interest.

Found In 1 Herb

Agarikon

Mushroom

3D Molecular Structure

Lanostane triterpenoid (Agarikon-specific)

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Officinalic acid

Lanostane triterpenoid (Agarikon-specific)Modified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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