Nuciferine
In vitro / AnimalMechanism of Action
Research Notes
Primary psychoactive alkaloid in Nymphaea caerulea. In vitro studies demonstrate dopamine antagonism in low micromolar concentrations. Animal models show CNS depression and anxiolytic-like effects. Research suggests potential antipsychotic properties (via dopamine antagonism) and neuroprotective effects (via sigma-1 activation), but human pharmacokinetics and bioavailability poorly characterized. Euphoric effects observed in traditional use may result from dopamine antagonism at low doses creating distinctive psychopharmacological state.
Anti-obesity and sedative effects in animal models; antiarrhythmic potential
Found In 2 Herbs
3D Molecular Structure
Nuciferine
Representative pattern: C₉H₇N₂O
Related Compounds (Isoquinoline alkaloid - aporphine-type)
Live Research
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