Nordihydroguaiaretic acid (NDGA)

In vitro

Mechanism of Action

Potent inhibitor of 5-lipoxygenase and 12-lipoxygenase; scavenges superoxide, hydroxyl, and peroxyl radicals; inhibits lipid peroxidation; disrupts viral replication through multiple mechanisms; induces apoptosis in cancer cell lines via p53 and caspase activation

Research Notes

ChaparralWestern

NDGA is one of the most potent natural antioxidants identified, with activity exceeding alpha-tocopherol. In vitro studies demonstrate broad-spectrum antiviral activity (HSV, HIV, HPV), antifungal effects, and selective cytotoxicity against multiple cancer cell lines. A methylated NDGA derivative (terameprocol) entered clinical trials for HPV-related cervical dysplasia and cancer. However, whole-herb use is associated with idiosyncratic hepatotoxicity.

Found In 1 Herb

Chaparral

Western

3D Molecular Structure

Lignan

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Nordihydroguaiaretic acid (NDGA)

LignanPlant polyphenols with antioxidant and estrogenic activity

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Related Compounds (Lignan)

Arctigenin(1)Arctiin(1)Cedrin(1)Phyllyrin(1)Sesamin(1)Sesamolin(1)

Live Research

Open on PubMed

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