Myristicin

Clinical trial

Mechanism of Action

Weak MAO inhibition; metabolised to MMDA-like amphetamine derivative (3-methoxy-4,5-methylenedioxyamphetamine); serotonergic activity; hepatotoxic at high dose

Inhibits monoamine oxidase (MAO), increasing catecholamine availability; stimulates renal blood flow and glomerular filtration; hepatoprotective through glutathione S-transferase induction

Psychoactive phenylpropanoid found in parsnip seed essential oil; contributes to carminative effect

Research Notes

Nutmeg (Jatiphala)Ayurvedic

Responsible for psychoactive effects of nutmeg intoxication. MAO inhibitory and serotonergic activity explain antidepressant potential at low doses and toxicity at high doses.

ParsleyWestern

Myristicin demonstrates MAO inhibitory activity and hepatoprotective effects in animal models. It is the primary constituent responsible for parsley's diuretic action. Large doses can be psychoactive (as seen with nutmeg intoxication). Therapeutic doses in parsley are well below psychoactive thresholds.

Wild ParsnipWestern

Carminative phenylpropanoid also found in nutmeg. Preclinical evidence for antioxidant and insecticidal activity.

Found In 3 Herbs

3D Molecular Structure

Phenylpropanoid (allylbenzene)

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Myristicin

Phenylpropanoid (allylbenzene)Bioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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