Muirapuamine (Ptychopetaline)

In vitro / Animal

Mechanism of Action

Proposed acetylcholinesterase inhibition based on molecular docking studies, potentially enhancing cholinergic neurotransmission in cognitive centres; dopaminergic modulation via partial D2 receptor affinity may contribute to pro-sexual and motivational effects. Exact in vivo mechanism not fully established.

Research Notes

Muira PuamaSouth American

Muirapuamine is the primary alkaloidal constituent unique to Ptychopetalum spp. In vitro acetylcholinesterase inhibitory activity has been demonstrated, with IC50 values in the low micromolar range in one Brazilian study. Animal models show enhanced acquisition and retention of memory tasks with Ptychopetalum extracts. Human data are limited to open-label studies of the whole extract, not isolated muirapuamine.

Found In 1 Herb

Muira Puama

South American

3D Molecular Structure

Phenylethylamine-derived alkaloid

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Muirapuamine (Ptychopetaline)

Phenylethylamine-derived alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

Open on PubMed

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