Meshimakobnol A and B

In vitro

Mechanism of Action

Drimane-type sesquiterpenes isolated from the fruiting body of P. linteus. Demonstrate anti-inflammatory activity by inhibiting inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in lipopolysaccharide-stimulated macrophages, reducing NO and PGE2 production. Also show moderate antioxidant activity via DPPH radical scavenging.

Research Notes

Meshima (Sang Hwang)Mushroom

Lee et al. (2008) isolated meshimakobnol A and B from methanol extracts of P. linteus fruiting body and demonstrated dose-dependent inhibition of NO production in RAW 264.7 macrophages (IC50 approximately 20–35 μM for meshimakobnol A). Anti-inflammatory activity was comparable to the positive control indomethacin at equivalent concentrations. No in vivo or clinical studies with isolated meshimakobnols have been published.

Found In 1 Herb

Meshima (Sang Hwang)

Mushroom

3D Molecular Structure

Sesquiterpene (drimane-type)

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Meshimakobnol A and B

Sesquiterpene (drimane-type)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

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