Loading…
Back to Compound Explorer
Mesembrine
Mechanism established in vitro; limited clinical trial data; primarily animal model evidenceMechanism of Action
Serotonin reuptake inhibitor at the serotonin transporter (SERT); mechanism distinct from SSRIs but with similar functional outcome; may also interact with trace amine-associated receptor 1 (TAAR1)
Research Notes
KannaSouth American
Primary active alkaloid; isolated and characterized in 2001. In vitro research demonstrates IC50 for serotonin reuptake inhibition in low micromolar range. Animal models show antidepressant-like effects in forced swim test and other depression models. Human clinical data limited; one small randomized controlled trial showed efficacy comparable to citalopram for mild-to-moderate depression. Bioavailability and pharmacokinetics poorly characterized in humans.
Found In 1 Herb
3D Molecular Structure
Alkaloid - phenethylamine derivative
Drag to rotate · Click atoms to explore
Mesembrine
Alkaloid - phenethylamine derivativeNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Alkaloid - phenethylamine derivative)
Live Research
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.