AlertsSign in
Back to Compound Explorer

Mesembrine

Mechanism established in vitro; limited clinical trial data; primarily animal model evidence
Alkaloid - phenethylamine derivative

Mechanism of Action

Serotonin reuptake inhibitor at the serotonin transporter (SERT); mechanism distinct from SSRIs but with similar functional outcome; may also interact with trace amine-associated receptor 1 (TAAR1)

Research Notes

KannaSouth American

Primary active alkaloid; isolated and characterized in 2001. In vitro research demonstrates IC50 for serotonin reuptake inhibition in low micromolar range. Animal models show antidepressant-like effects in forced swim test and other depression models. Human clinical data limited; one small randomized controlled trial showed efficacy comparable to citalopram for mild-to-moderate depression. Bioavailability and pharmacokinetics poorly characterized in humans.

Found In 1 Herb

Kanna

Kanna

South American

3D Molecular Structure

Alkaloid - phenethylamine derivative
Drag to rotate · Click atoms to explore

Mesembrine

Alkaloid - phenethylamine derivativeNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms
Nitrogen
Carbon
Hydrogen
Oxygen

Related Compounds (Alkaloid - phenethylamine derivative)

Mesembrenol(1)Mesembrenone(1)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.