Mangiferin

In vitro / Animal

Mechanism of Action

Antioxidant, anti-diabetic via α-glucosidase inhibition, anti-inflammatory via NF-kB, neuroprotective

Potent antioxidant via direct ROS scavenging and upregulation of endogenous antioxidant enzymes; activates AMPK pathway for glucose uptake; inhibits α-glucosidase; anti-inflammatory via NF-κB and COX pathway suppression; antiviral activity against herpes simplex and influenza in vitro.

Research Notes

Anemarrhena (Zhi Mu)TCM

Significant anti-diabetic effects in multiple animal models. Anti-inflammatory comparable to indomethacin in carrageenan models. Neuroprotective in Alzheimer's models via Aβ reduction.

HoneybushAfrican

Extensively studied xanthone with strong in vitro antioxidant, anti-inflammatory, and antidiabetic data. Characteristic marker compound for Honeybush quality assessment. Human clinical data from Honeybush-specific preparations remain limited.

Found In 2 Herbs

Anemarrhena (Zhi Mu)

TCM

Honeybush

African

3D Molecular Structure

Xanthone glycoside

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Mangiferin

Xanthone glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Related Compounds (Xanthone glycoside)

Amarogentin(1)

Live Research

Open on PubMed

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