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Luteolin-7-glucoside

Preliminary
Flavone glycoside (flavonoid)

Mechanism of Action

Luteolin-7-O-glucoside is hydrolyzed in the gastrointestinal tract to free luteolin, which exhibits broad anti-inflammatory and antioxidant activity. Luteolin directly inhibits IκB kinase (IKK), preventing phosphorylation and degradation of IκB and subsequent NF-κB nuclear translocation. This reduces transcription of pro-inflammatory genes including COX-2, iNOS, TNF-α, IL-1β, and IL-6. Luteolin also inhibits phosphodiesterase (PDE) activity, elevating intracellular cAMP and promoting anti-inflammatory M2 macrophage polarization. Mast cell stabilization through inhibition of IgE-mediated degranulation contributes to antiallergic effects. Bioavailability is moderate, with peak plasma concentrations reached at 1–2 hours post-ingestion.

Research Notes

CleaversWestern

Luteolin, including its glycosidic forms, has been extensively studied in vitro and in animal models, demonstrating consistent anti-inflammatory, antioxidant, and antiallergic activity. Multiple systematic reviews confirm NF-κB and MAPK pathway inhibition across diverse inflammatory cell types. Human clinical data are sparse for luteolin specifically, but a small double-blind study in middle-aged and older adults showed 100 mg/day luteolin-containing extract reduced neuroinflammation biomarkers and improved memory scores over 4 weeks. Cleavers-specific luteolin content is modest compared to dedicated luteolin sources (artichoke, celery), and its contribution to the herb's lymphatic effects has not been isolated clinically.

Found In 1 Herb

Cleavers

Cleavers

Western

3D Molecular Structure

Flavone glycoside (flavonoid)
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Luteolin-7-glucoside

Flavone glycoside (flavonoid)Polyphenolic antioxidants protecting cells from oxidative damage

Representative pattern: C₁₅H₁₀O₃

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.