Luteolin-7-glucoside

Preliminary

Mechanism of Action

Luteolin-7-O-glucoside is hydrolyzed in the gastrointestinal tract to free luteolin, which exhibits broad anti-inflammatory and antioxidant activity. Luteolin directly inhibits IκB kinase (IKK), preventing phosphorylation and degradation of IκB and subsequent NF-κB nuclear translocation. This reduces transcription of pro-inflammatory genes including COX-2, iNOS, TNF-α, IL-1β, and IL-6. Luteolin also inhibits phosphodiesterase (PDE) activity, elevating intracellular cAMP and promoting anti-inflammatory M2 macrophage polarization. Mast cell stabilization through inhibition of IgE-mediated degranulation contributes to antiallergic effects. Bioavailability is moderate, with peak plasma concentrations reached at 1–2 hours post-ingestion.

Research Notes

CleaversWestern

Luteolin, including its glycosidic forms, has been extensively studied in vitro and in animal models, demonstrating consistent anti-inflammatory, antioxidant, and antiallergic activity. Multiple systematic reviews confirm NF-κB and MAPK pathway inhibition across diverse inflammatory cell types. Human clinical data are sparse for luteolin specifically, but a small double-blind study in middle-aged and older adults showed 100 mg/day luteolin-containing extract reduced neuroinflammation biomarkers and improved memory scores over 4 weeks. Cleavers-specific luteolin content is modest compared to dedicated luteolin sources (artichoke, celery), and its contribution to the herb's lymphatic effects has not been isolated clinically.

Found In 1 Herb

Cleavers

Western

3D Molecular Structure

Flavone glycoside (flavonoid)

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