Luteolin-7-diglucuronide

Preliminary

Mechanism of Action

Inhibits phosphodiesterase (PDE4) — the primary cAMP-degrading enzyme in immune and smooth muscle cells — raising intracellular cAMP levels and promoting bronchodilation and anti-inflammatory signaling. Inhibits Th2-mediated immune responses (IL-4, IL-13 suppression), relevant to atopic and allergic conditions. Antispasmodic on intestinal smooth muscle via calcium antagonism.

Research Notes

Lemon VerbenaWestern

Luteolin glycosides from lemon verbena have been quantified in both dried herb preparations and pharmacokinetic studies demonstrating systemic bioavailability after oral ingestion. Anti-inflammatory activity of luteolin has strong preclinical support across multiple inflammatory pathway studies. Direct clinical evidence for lemon verbena-derived luteolin specifically is limited; broader luteolin clinical trials support the mechanism.

Found In 1 Herb

Lemon Verbena

Western

3D Molecular Structure

Flavone glycoside

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Luteolin-7-diglucuronide

Flavone glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Related Compounds (Flavone glycoside)

Baicalin(2)Flavonoids (apiin, isovitexin)(1)Flavonoids (luteolin-7-glucoside, apigenin glycosides)(1)

Live Research

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.