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Luteolin-7-diglucuronide
PreliminaryMechanism of Action
Inhibits phosphodiesterase (PDE4) — the primary cAMP-degrading enzyme in immune and smooth muscle cells — raising intracellular cAMP levels and promoting bronchodilation and anti-inflammatory signaling. Inhibits Th2-mediated immune responses (IL-4, IL-13 suppression), relevant to atopic and allergic conditions. Antispasmodic on intestinal smooth muscle via calcium antagonism.
Research Notes
Lemon VerbenaWestern
Luteolin glycosides from lemon verbena have been quantified in both dried herb preparations and pharmacokinetic studies demonstrating systemic bioavailability after oral ingestion. Anti-inflammatory activity of luteolin has strong preclinical support across multiple inflammatory pathway studies. Direct clinical evidence for lemon verbena-derived luteolin specifically is limited; broader luteolin clinical trials support the mechanism.
Found In 1 Herb
3D Molecular Structure
Flavone glycoside
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Luteolin-7-diglucuronide
Flavone glycosideSugar-bound molecules that control drug release in the body
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
Related Compounds (Flavone glycoside)
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