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Lupeol

In vitro / Animal
Pentacyclic triterpene

Mechanism of Action

Anti-inflammatory, anti-arthritic, and antimicrobial activity
Anti-inflammatory via NF-kB and TNF-alpha inhibition; analgesic; anti-arthritic through cartilage protection
Anti-inflammatory via inhibition of NF-κB signalling and downstream COX-2 expression; anti-androgenic activity documented in prostate cell models (paradoxically, prostate-protective); antidiabetic effects via PPAR-γ agonism in preclinical models; anti-leishmanial activity through mitochondrial membrane disruption in the parasite.

Research Notes

AlderWestern

Documented anti-inflammatory and antimicrobial properties in animal models and in vitro studies.

DashamoolaAyurvedic

Lupeol from Agnimantha is one of the key active triterpenoids in Dashamoola. In vitro and animal studies demonstrate significant anti-inflammatory and analgesic activity.

Muira PuamaSouth American

Lupeol is widely distributed across medicinal plants and is among the better-characterised triterpenoids. Consistent anti-inflammatory and hepatoprotective activity in rodent models; prostate protective effects in TRAMP mouse carcinogenesis models. Its contribution to Muira Puama's aphrodisiac effects is indirect at best; it is more relevant to the anti-inflammatory and trophic tissue-supporting aspects of the herb's adaptogenic profile.

Found In 3 Herbs

Alder

Alder

Western
Dashamoola

Dashamoola

Ayurvedic
Muira Puama

Muira Puama

South American

3D Molecular Structure

Pentacyclic triterpene
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Lupeol

Pentacyclic triterpeneAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms
Carbon
Oxygen
Hydrogen

Related Compounds (Pentacyclic triterpene)

Acetyl-11-keto-β-boswellic acid (AKBA)(1)AKBA (3-O-Acetyl-11-keto-β-boswellic acid)(1)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.