LEM (Lentinula Edodes Mycelium extract)

Clinical trial

Water-soluble mycelium extract (heterogeneous polysaccharide/lignan/protein mixture)

Mechanism of Action

Contains a complex mixture of polysaccharides, lignans (EP3), and glycoproteins. The lignan fraction (EP3) demonstrates direct antiviral activity by inhibiting viral reverse transcriptase and protease enzymes. Polysaccharide components activate macrophages and enhance interferon production. Also shows hepatoprotective effects via glutathione upregulation and suppression of hepatic stellate cell activation.

Research Notes

ShiitakeMushroom

Aoki et al. (1987) demonstrated that LEM suppressed hepatitis B surface antigen (HBsAg) in chronic hepatitis B carriers in a controlled trial. Suzuki et al. (1990) showed LEM improved liver function markers in chronic hepatitis patients. Gordon et al. (1998) published a pilot study of LEM in HIV patients showing trends toward improved CD4 counts and reduced viral load. Anti-hepatitis and hepatoprotective effects are best documented; oncology data is limited to preclinical models.

Found In 1 Herb

Shiitake

Mushroom

3D Molecular Structure

Water-soluble mycelium extract (heterogeneous polysaccharide/lignan/protein mixture)

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LEM (Lentinula Edodes Mycelium extract)

Water-soluble mycelium extract (heterogeneous polysaccharide/lignan/protein mixture)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.