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Kolaviron

In vitro / Animal
Biflavonoid complex (GB1 + GB2 + kolaflavanone)

Mechanism of Action

Activates Nrf2/HO-1 antioxidant response element pathway, suppresses NF-κB and MAPK pro-inflammatory signalling cascades, inhibits CYP2E1-mediated hepatotoxic bioactivation, enhances superoxide dismutase and catalase activity, and inhibits α-glucosidase and α-amylase for glycaemic modulation.
Inhibits NF-κB signalling and COX-2 expression; scavenges reactive oxygen species; upregulates hepatic antioxidant enzymes (SOD, CAT, GST); modulates Nrf2 pathway.

Research Notes

Bitter KolaAfrican

Extensive preclinical evidence in rodent models shows kolaviron protects against carbon tetrachloride-, alcohol-, and aflatoxin-induced hepatotoxicity; reduces fasting blood glucose comparably to glibenclamide in diabetic models; and demonstrates broad-spectrum antimicrobial and anti-inflammatory activity. Phase I human safety data from Nigerian academic centres indicate tolerability; Phase II efficacy trials in hepatic and diabetic endpoints are ongoing as of 2024.

Bitter KolaAfrican

Multiple rodent studies demonstrate hepatoprotective activity against carbon tetrachloride and acetaminophen-induced liver injury. Anti-inflammatory and antidiabetic effects have been documented in vitro and in vivo, though human clinical trials remain limited.

Found In 2 Herbs

Bitter Kola

Bitter Kola

African
Bitter Kola

Bitter Kola

African

3D Molecular Structure

Biflavonoid complex (GB1 + GB2 + kolaflavanone)
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Kolaviron

Biflavonoid complex (GB1 + GB2 + kolaflavanone)Polyphenolic antioxidants protecting cells from oxidative damage

Representative pattern: C₁₅H₁₀O₃

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.