Jujuboside B

Preliminary

Mechanism of Action

Jujuboside B shares structural similarity with jujuboside A and similarly modulates GABAergic neurotransmission, though with a somewhat different receptor subunit selectivity profile. It has been shown to inhibit hippocampal neuronal excitability through enhancement of tonic GABA-A inhibition and to reduce the expression of excitatory amino acid transporters, thereby indirectly increasing inhibitory tone in cortical circuits involved in sleep-wake regulation.

Research Notes

Suan Zao RenTCM

Preclinical studies in mice demonstrated that jujuboside B at 25 mg/kg significantly prolonged pentobarbital-induced sleeping time and reduced locomotor activity. A 2017 study in the Journal of Ethnopharmacology showed that jujuboside B decreased c-Fos expression in wake-promoting orexinergic neurons of the lateral hypothalamus while increasing it in sleep-active ventrolateral preoptic neurons. Synergistic effects with jujuboside A have been reported in combination studies.

Found In 1 Herb

Suan Zao Ren

TCM

3D Molecular Structure

Dammarane-type triterpenoid saponin

Drag to rotate · Click atoms to explore

Jujuboside B

Dammarane-type triterpenoid saponinModified terpenes with diverse biological activities

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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