Jujuboside A

Clinical trial

Mechanism of Action

Sedative and hypnotic via GABAergic enhancement; anxiolytic; inhibits hippocampal glutamate excitotoxicity

Jujuboside A acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory GABAergic neurotransmission in the hypothalamus and hippocampus. It increases chloride ion influx through GABA-A receptor channels, promoting neuronal hyperpolarization and reducing neuronal excitability. Additionally, jujuboside A has been shown to inhibit glutamatergic excitatory transmission and modulate the hypothalamic-pituitary-adrenal (HPA) axis, reducing corticosterone levels and attenuating stress-induced wakefulness.

Research Notes

Jujube (Da Zao)TCM

Jujuboside A is the primary sedative compound. Animal studies confirm sedative-hypnotic effects. Clinical use for insomnia has traditional and modern support.

Suan Zao RenTCM

Animal studies have demonstrated that jujuboside A significantly increases total sleep time and reduces sleep latency in pentobarbital-induced sleep models in mice, with effects comparable to diazepam at doses of 10–40 mg/kg. A 2019 study published in Biomedicine & Pharmacotherapy showed that jujuboside A promoted sleep by upregulating GABA-A receptor alpha-1 subunit expression in the hippocampus. In vitro electrophysiology studies confirmed its direct potentiation of GABA-evoked currents in cultured hippocampal neurons.

Found In 2 Herbs

Jujube (Da Zao)

TCM

Suan Zao Ren

TCM

3D Molecular Structure

Triterpenoid saponin (dammarane-type)

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Jujuboside A

Triterpenoid saponin (dammarane-type)Modified terpenes with diverse biological activities

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Related Compounds (Triterpenoid saponin (dammarane-type))

Bacoside A(2)Gypenosides(1)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.