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Isothiocyanates (Moringin / 4-O-α-L-rhamnosyloxy-benzyl isothiocyanate)
ModerateMechanism of Action
Generated from glucosinolate precursors via myrosinase during tissue disruption; potently inhibits NF-κB signalling and downstream pro-inflammatory cytokine production (IL-6, TNF-α, IL-1β); induces Nrf2-mediated antioxidant response element (ARE) activation, upregulating Phase II detoxification enzymes (glutathione S-transferase, NAD(P)H quinone oxidoreductase); demonstrates direct antimicrobial activity by reacting with sulfhydryl groups in bacterial cysteine proteases.
Research Notes
MoringaAfrican
In vitro and rodent studies confirm robust anti-inflammatory, cytoprotective, and antimicrobial activity. A 2021 randomised controlled trial (n=120) in type 2 diabetic patients found that 4 g/day of Moringa leaf powder over 12 weeks significantly reduced fasting blood glucose (−18%) and HbA1c (−0.7%). Antioxidant and hepatoprotective effects are consistently demonstrated in preclinical models; human clinical data are emerging.
Found In 1 Herb
3D Molecular Structure
Glucosinolate hydrolysis product
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Isothiocyanates (Moringin / 4-O-α-L-rhamnosyloxy-benzyl isothiocyanate)
Glucosinolate hydrolysis productBioactive phytochemical with therapeutic properties
Representative pattern: C₄H₂NO
Atoms
Carbon
Oxygen
Nitrogen
Hydrogen
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