Interfungins A

In vitro

Phenyl polyketide (novel natural product)

Mechanism of Action

Interfungins A is a chlorinated phenyl polyketide first isolated from P. linteus mycelium. It inhibits protein tyrosine phosphatase 1B (PTP1B), an enzyme that negatively regulates insulin and leptin signaling and is also implicated in cancer cell survival. By inhibiting PTP1B, interfungins A may enhance anti-tumor immune responses and directly suppress tumor cell proliferation through restoration of receptor tyrosine kinase signaling fidelity.

Research Notes

Meshima (Sang Hwang)Mushroom

Yousaf et al. (2008) first isolated and characterized interfungins A from P. linteus mycelial culture, demonstrating PTP1B inhibition with IC50 of 6.1 μM. Subsequent studies have explored PTP1B inhibition as both an anti-cancer and anti-diabetic target. The compound remains in early preclinical investigation with no animal efficacy studies or clinical trials published. Its novelty as a natural PTP1B inhibitor makes it a compound of pharmacological interest beyond its mushroom context.

Found In 1 Herb

Meshima (Sang Hwang)

Mushroom

3D Molecular Structure

Phenyl polyketide (novel natural product)

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Interfungins A

Phenyl polyketide (novel natural product)Bioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

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