Inotodiol

Inotodiol was identified as the dominant lanostane triterpene in Chaga sclerotia by Kahlos et al. (1996, Planta Medica). It demonstrated anti-inflammatory and antitumor activity in vitro in multiple cell line studies (Nomura et al., 2008, Bioorganic & Medicinal Chemistry Letters). Proproliferative effects on dermal papilla cells were demonstrated in a 2019 in vitro study (Lee et al., PubMed ID: 30706371). Found in BOTH wild sclerotia and cultivated mycelium, though concentrations are substantially higher in wild specimens. Cultivated fruiting bodies have lower inotodiol but much higher ergosterol (27% vs. trace in sclerotia).