Indirubin

Clinical trial

Bisindole (indole alkaloid)

Mechanism of Action

CDK2 inhibition; anti-leukemic via cell cycle arrest; anti-inflammatory through STAT3 inhibition

CDK2/cyclin E inhibition, GSK-3β inhibition, anti-leukemic, anti-inflammatory via AhR (aryl hydrocarbon receptor)

CDK inhibition (cyclin-dependent kinase); anti-inflammatory; antiviral; antileukaemic

Anti-inflammatory; CDK inhibition; anti-leukemic; antiviral via interferon induction

CDK inhibition, anti-leukemic, anti-inflammatory, antiviral

Research Notes

Dyers Woad Root (Jin Dai)TCM

Indirubin gained clinical validation treating chronic myelogenous leukemia in the 1970s-80s with complete remission in a significant proportion of patients.

Indigo (Qing Dai)TCM

Historically used in CML treatment in China before imatinib era. CDK inhibition confirmed as mechanism. Anti-psoriatic effects via AhR activation — basis for topical psoriasis use.

Isatis (Woad)Western

Used in traditional Chinese leukaemia treatment; indirubin and analogues are potent CDK2/GSK-3β inhibitors; synthetic analogues in clinical trials for CML and other cancers

Isatis Leaf (Da Qing Ye)TCM

Indirubin from Isatis leaf has anti-inflammatory and antiviral properties. Clinical use in China for respiratory viral infections and leukemia.

Isatis Root (Ban Lan Gen)TCM

Antiviral activity against influenza, hepatitis, and SARS-CoV in vitro studies. Same compound as in Qing Dai but at lower concentration in root. Anti-inflammatory via multiple pathways.

Found In 5 Herbs

3D Molecular Structure

Bisindole (indole alkaloid)

Drag to rotate · Click atoms to explore

Indirubin

Bisindole (indole alkaloid)Nitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.