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Hypoxoside
PreliminaryMechanism of Action
Hydrolysed by intestinal beta-glucosidase to rooperol (the active catechol norlignan aglycone); hypoxoside itself is pharmacologically inert but serves as a bioavailable prodrug form. Rate and extent of conversion varies with intestinal microbiota composition, explaining inter-individual variability in clinical response.
Research Notes
African PotatoAfrican
Hypoxoside has been demonstrated to convert reliably to rooperol in vivo in human pharmacokinetic studies. Orally administered hypoxoside achieves measurable rooperol plasma levels within 1–2 hours. Standardisation of raw corm preparations to hypoxoside content (0.3–1.2% w/w dried corm) is feasible by HPLC. The prodrug approach avoids premature catechol oxidation that would render rooperol inactive before absorption.
Found In 1 Herb
3D Molecular Structure
Norlignan glucoside (prodrug)
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Hypoxoside
Norlignan glucoside (prodrug)Plant polyphenols with antioxidant and estrogenic activity
Representative pattern: C₄H₂NO
Atoms
Carbon
Oxygen
Nitrogen
Hydrogen
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