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Hypericin

Clinical trial
Naphthodianthrone (polycyclic dione)

Mechanism of Action

Monoamine reuptake inhibition (serotonin, dopamine, norepinephrine); anti-inflammatory and antioxidant through polyphenol action; MAOI activity
Antidepressant and antiviral naphthodianthrone; present at lower levels than in H. perforatum; photosensitizing

Research Notes

St. John's WortWestern

Hypericin is the primary naphthodianthrone in St. John's Wort demonstrating antidepressant effects equivalent to tricyclic antidepressants in clinical trials. Mood enhancement and anxiolytic effects reduce pain perception; relevant for neuropathic pain and pain with depressive component.

TustanWestern

Hypericin is the characteristic naphthodianthrone of Hypericum species. Antidepressant mechanism via monoamine modulation. Lower concentration in H. androsaemum than H. perforatum.

Found In 2 Herbs

St. John's Wort

St. John's Wort

Western
Tustan

Tustan

Western

3D Molecular Structure

Naphthodianthrone (polycyclic dione)
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Hypericin

Naphthodianthrone (polycyclic dione)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms
Carbon
Oxygen
Nitrogen
Hydrogen

Live Research

Open on PubMed

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