Hyperforin

In vitro

Phloroglucinol derivative (prenylated hydroquinone)

Mechanism of Action

Synaptic monoamine transporter inhibition; CYP3A4 and P-glycoprotein induction (major pharmacokinetic mechanism); anti-inflammatory through NF-κB modulation

Key reuptake inhibitor for serotonin, dopamine, and noradrenaline; lower concentration than in H. perforatum; CYP3A4 induction potential

Research Notes

St. John's WortWestern

Hyperforin is the primary bioactive responsible for most antidepressant and cytochrome P450-inducing effects of St. John's Wort. CRITICAL: Hyperforin induces CYP3A4 and P-glycoprotein, reducing efficacy of numerous medications by 20-60%, including warfarin, oral contraceptives, statins, protease inhibitors, and others.

TustanWestern

Hyperforin is established as a non-selective monoamine reuptake inhibitor and CYP3A4 inducer. Lower levels in H. androsaemum suggest reduced potency and drug interaction risk.

Found In 2 Herbs

St. John's Wort

Western

Tustan

Western

3D Molecular Structure

Phloroglucinol derivative (prenylated hydroquinone)

Drag to rotate · Click atoms to explore

Hyperforin

Phloroglucinol derivative (prenylated hydroquinone)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.