Hispidin

In vitro / Animal

Styrylpyrone (phenylpropanoid-polyketide hybrid)

Mechanism of Action

Hispidin is a natural phenolic compound with a styrylpyrone scaffold that exhibits potent antioxidant activity through direct scavenging of reactive oxygen species (ROS) including superoxide anion, hydroxyl radicals, and hydrogen peroxide. It inhibits protein kinase C (PKC) beta isoforms, which are involved in oxidative stress signaling and diabetic complications. Hispidin also activates the Nrf2/ARE (antioxidant response element) pathway, upregulating endogenous antioxidant enzymes including heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutathione S-transferase. Additionally, it suppresses NF-kB-mediated inflammatory signaling and has demonstrated direct cytotoxic effects against cancer cell lines through induction of apoptosis.

Research Notes

Sang HuangMushroom

Hispidin has been identified across multiple Phellinus and Inonotus species and is considered a chemotaxonomic marker for the Hymenochaetaceae family. In vitro studies demonstrated dose-dependent cytotoxicity against various cancer cell lines including hepatocellular carcinoma and gastric cancer. A study on beta-cell protection showed hispidin significantly reduced peroxynitrite-mediated damage in pancreatic beta cells, suggesting potential applications in diabetes. Antioxidant capacity assays consistently rank hispidin among the most potent natural phenolic antioxidants.

Found In 1 Herb

Sang Huang

Mushroom

3D Molecular Structure

Styrylpyrone (phenylpropanoid-polyketide hybrid)

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Hispidin

Styrylpyrone (phenylpropanoid-polyketide hybrid)Bioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Live Research

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