Hericenones C, D, E, H

Moderate

Cyathane diterpenoid derivatives (aromatic compounds)

Mechanism of Action

Hericenones are aromatic compounds isolated exclusively from the fruiting body. They stimulate synthesis of nerve growth factor (NGF) in astroglial cells by activating the JNK signaling pathway. Hericenones C and D are the most potent NGF inducers in the series. They are lipophilic and can cross the blood-brain barrier, promoting neuronal differentiation and neurite outgrowth in PC12 cells.

Research Notes

Lion's ManeMushroom

Kawagishi et al. (1991, Tetrahedron Letters) first isolated hericenones C–H from H. erinaceus fruiting bodies and demonstrated NGF-stimulating activity in vitro in rat astroglial cells. Subsequent studies confirmed that hericenones C and D induce NGF mRNA expression at concentrations of 33 µg/mL. These compounds are found ONLY in the fruiting body, not in mycelium — a critical distinction for product formulation and label claims.

Found In 1 Herb

Lion's Mane

Mushroom

3D Molecular Structure

Cyathane diterpenoid derivatives (aromatic compounds)

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Hericenones C, D, E, H

Cyathane diterpenoid derivatives (aromatic compounds)Modified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

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