Helenalin

Clinical trial

Sesquiterpene lactone (α,β-unsaturated γ-lactone)

Mechanism of Action

Inhibits NF-κB and AP-1 signaling in topical application; reduces TNF-α, IL-1β, IL-6; blocks pro-inflammatory gene transcription

Research Notes

ArnicaWestern

Helenalin is the primary active sesquiterpene lactone in arnica, demonstrating potent anti-inflammatory and antimicrobial effects in topical preparations. Clinical trials support efficacy for bruising, swelling, and muscle soreness when applied topically; contraindicated internally due to toxicity.

Found In 1 Herb

Arnica

Western

3D Molecular Structure

Sesquiterpene lactone (α,β-unsaturated γ-lactone)

Drag to rotate · Click atoms to explore

Helenalin

Sesquiterpene lactone (α,β-unsaturated γ-lactone)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.