Harpagoside

Clinical trial

Iridoid glycoside (monoterpene ester glucoside)

Mechanism of Action

Inhibits NF-κB signaling, reduces TNF-α and IL-6 production; potentiates anti-inflammatory gene expression

Inhibits NF-κB nuclear translocation, suppresses COX-2 and iNOS transcription, reduces TNF-α and IL-1β production in macrophages; may modulate PPAR-γ to dampen inflammatory gene expression

Research Notes

Devil's ClawWestern

Harpagoside is the primary bioactive in devil's claw and demonstrates significant anti-inflammatory effects in clinical trials for osteoarthritis and low back pain. Studies show dose-dependent reduction in inflammatory markers and pain scores, with effects comparable to some NSAIDs.

Xuan Shen (Figwort Root)TCM

Harpagoside from Scrophularia ningpoensis demonstrates anti-inflammatory potency comparable to ibuprofen in carrageenan paw-edema animal models. In vitro studies show dose-dependent inhibition of NF-κB in LPS-stimulated RAW264.7 macrophages. Limited human clinical data; most evidence from Harpagophytum (devil's claw) extracts containing the same compound.

Found In 2 Herbs

Devil's Claw

Western

Xuan Shen (Figwort Root)

TCM

3D Molecular Structure

Iridoid glycoside (monoterpene ester glucoside)

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Harpagoside

Iridoid glycoside (monoterpene ester glucoside)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Related Compounds (Iridoid glycoside (monoterpene ester glucoside))

Loganin(2)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.