Hanabiratakelide

In vitro

Mechanism of Action

Hanabiratakelide is a resorcylic acid lactone unique to Sparassis crispa that inhibits the TAK1-mediated NF-κB activation pathway, suppressing downstream expression of pro-inflammatory mediators including TNF-α, IL-6, and COX-2. This mechanism targets an upstream kinase in the inflammatory cascade, providing broader anti-inflammatory coverage than direct COX inhibition alone.

Research Notes

Cauliflower MushroomMushroom

Hanabiratakelide was isolated from S. crispa fruiting bodies by Yoshikawa et al. and demonstrated dose-dependent inhibition of NF-κB activation in cell-based reporter assays. Anti-inflammatory activity was confirmed through suppression of LPS-induced cytokine production in murine macrophages. The compound is considered a chemotaxonomic marker for Sparassis species. All evidence is in vitro.

Found In 1 Herb

Cauliflower Mushroom

Mushroom

3D Molecular Structure

Beta-resorcylic acid lactone

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Hanabiratakelide

Beta-resorcylic acid lactoneCyclic esters with diverse pharmacological activities

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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