Gymnemic Acids (I–VII)

Strong

Pentacyclic triterpenoid saponins (oleanane backbone)

Mechanism of Action

Competitively block sweet taste receptors (T1R2/T1R3), inhibit SGLT1 on enterocyte brush border, stimulate pancreatic beta-cell regeneration via PDX-1/Pax4 transcription factors, and activate lipolysis through PPARα upregulation.

Research Notes

Gymnema SylvestreAyurvedic

Shanmugasundaram et al. (1990) showed GS4 extract (400 mg/day × 18–20 months) reduced fasting blood glucose from 174.3 to 124.0 mg/dL and HbA1c from 11.91 to 8.48% in 22 Type 2 diabetic patients. A 2014 meta-analysis (n=322) confirmed significant reductions in fasting glucose and postprandial glucose.

Found In 1 Herb

Gymnema Sylvestre

Ayurvedic

3D Molecular Structure

Pentacyclic triterpenoid saponins (oleanane backbone)

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Gymnemic Acids (I–VII)

Pentacyclic triterpenoid saponins (oleanane backbone)Modified terpenes with diverse biological activities

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

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