Grifolan

In vitro / Animal

Mechanism of Action

Binds complement receptor 3 (CR3) on leukocytes, activating the complement system and enhancing opsonization and phagocytosis of pathogens and abnormal cells. Unlike the branched D-fraction glucans, grifolan is a more linear beta-1,3-glucan that activates different arms of the innate immune system, particularly the complement cascade.

Research Notes

MaitakeMushroom

Adachi et al. (1988, 1990) isolated grifolan from G. frondosa and demonstrated its anti-tumor activity in Sarcoma 180 mouse models, with complete regression in a subset of animals. Subsequent studies confirmed grifolan activates macrophages to secrete IL-1, IL-6, and TNF-α. Ohno et al. (1995) showed grifolan enhanced hematopoietic recovery in irradiated mice. All evidence is preclinical.

Found In 1 Herb

Maitake

Mushroom

3D Molecular Structure

Beta-1,3-glucan (linear polysaccharide)

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Grifolan

Beta-1,3-glucan (linear polysaccharide)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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