Ganoderic acids (G. applanatum profile)

Preliminary

Mechanism of Action

Inhibit histamine release from mast cells, suppress 5-alpha reductase activity, and modulate NF-kB signaling to reduce pro-inflammatory cytokine expression (TNF-alpha, IL-6). The triterpene profile in G. applanatum overlaps with but is quantitatively distinct from G. lucidum, with different ratios of individual ganoderic and ganoderenic acid isomers.

Research Notes

Artist's ConkMushroom

Comparative phytochemical analysis confirmed the presence of ganoderic acids in G. applanatum with a distinct quantitative profile from G. lucidum. In vitro and animal model studies demonstrated anti-inflammatory, immunomodulatory, and hepatoprotective effects. A Taylor & Francis study (2024) found 11 metabolites from G. applanatum with anticancer and anti-inflammatory properties, including induction of apoptosis through multiple pathways.

Found In 1 Herb

Artist's Conk

Mushroom

3D Molecular Structure

Lanostane triterpene (C30)

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Ganoderic acids (G. applanatum profile)

Lanostane triterpene (C30)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

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