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β-Eudesmol

Preliminary
Sesquiterpene alcohol

Mechanism of Action

Acts as a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist at the neuromuscular junction, with selective affinity for α3β4 and α4β2 receptor subtypes. Concurrently exhibits acetylcholinesterase inhibitory activity in central neural tissue, creating a complex and context-dependent cholinergic modulation profile. Additionally suppresses reactive oxygen species (ROS) generation in neurons via Nrf2/HO-1 pathway activation, inducing heme oxygenase-1 and NAD(P)H:quinone oxidoreductase-1 expression, conferring neuroprotective and antioxidant effects relevant to neurodegenerative disease models.

Research Notes

Bai ZhuTCM

Preclinical studies demonstrate significant neuroprotective effects in models of cerebral ischemia-reperfusion injury and amyloid-beta (Aβ1-42)-induced neuronal toxicity. A 2021 study in Phytomedicine reported significant cognitive improvement in senescence-accelerated mouse prone-8 (SAMP8) mice treated with β-eudesmol-enriched Atractylodes extract over 8 weeks, with reductions in hippocampal oxidative stress markers and improvements in Morris water maze performance. Structural analogs have been patented for neuromuscular blocking activity; clinical data for β-eudesmol specifically remain limited to observational pharmacokinetic reports.

Found In 1 Herb

Bai Zhu

Bai Zhu

TCM

3D Molecular Structure

Sesquiterpene alcohol
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β-Eudesmol

Sesquiterpene alcoholAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms
Carbon
Oxygen
Hydrogen

Related Compounds (Sesquiterpene alcohol)

Bisabolol(1)Himachalol(1)

Live Research

Open on PubMed

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