Eritadenine (lentysine, lentinacin)

Animal

Mechanism of Action

Inhibits S-adenosylhomocysteine hydrolase (SAHH), which disrupts the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. This shifts hepatic phospholipid ratios, reducing the assembly and secretion of VLDL cholesterol particles. Also accelerates removal of circulating LDL by upregulating hepatic LDL receptor expression. Mechanism is entirely distinct from statins (HMG-CoA reductase inhibition), fibrates, or bile acid sequestrants.

Research Notes

ShiitakeMushroom

Enman et al. (2007) confirmed eritadenine reduces total cholesterol by 25–30% in rats at 50 mg/kg/day. Sugiyama et al. (1995) elucidated the SAHH inhibition mechanism and PE/PC ratio alteration. Fukushima et al. (2001) demonstrated dose-dependent cholesterol reduction in rats fed shiitake-containing diets. Human data is limited to observational/dietary studies — no controlled trials with isolated eritadenine in humans have been published. Eritadenine is present at ~3–6 mg/g in dried shiitake fruiting body.

Found In 1 Herb

Shiitake

Mushroom

3D Molecular Structure

Purine alkaloid (adenosine derivative)

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Eritadenine (lentysine, lentinacin)

Purine alkaloid (adenosine derivative)Nitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

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