Erinacines (mycelial)

Moderate

Mechanism of Action

Erinacines are cyathane diterpenoids produced exclusively in the mycelium of Hericium species. They cross the blood-brain barrier and stimulate NGF synthesis in hippocampal and cortical astrocytes through activation of the JNK pathway and c-Jun transcription factor. This promotes neuronal survival, axonal growth, and remyelination. Erinacine A is the most potent NGF inducer in the series, with demonstrated activity at concentrations as low as 1 mM in cell culture.

Research Notes

Coral Tooth FungusMushroom

Erinacines have been most extensively studied in H. erinaceus, where they constitute the primary rationale for mycelium-based Lion's Mane supplements. Their presence in H. coralloides mycelium has been confirmed but is less comprehensively characterized in terms of quantity and diversity of individual erinacine variants. H. erinaceus clinical trials (multiple RCTs) demonstrating cognitive improvements in mild cognitive impairment patients likely reflect erinacine activity, and similar effects may be expected from H. coralloides mycelium, though this has not been directly confirmed.

Found In 1 Herb

Coral Tooth Fungus

Mushroom

3D Molecular Structure

Cyathane diterpenoid

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Erinacines (mycelial)

Cyathane diterpenoidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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