Ergosterol peroxide

Preliminary

Mechanism of Action

Ergosterol peroxide induces apoptosis in tumor cells through mitochondrial membrane depolarization and caspase-3 activation. It also modulates macrophage cytokine release, enhancing TNF-α and IFN-γ secretion. As a UV-activated precursor to vitamin D2, it contributes to the nutritional profile of the fruiting body.

Induces apoptosis in tumor cells through mitochondrial membrane depolarization and caspase-3 activation. Exhibits immunomodulatory activity by modulating macrophage cytokine release, enhancing TNF-alpha and IFN-gamma secretion. Also serves as a precursor to vitamin D2 upon UV exposure.

Research Notes

Cauliflower MushroomMushroom

Ergosterol peroxide has been identified in S. crispa fruiting bodies alongside ergosterol and other sterol derivatives. Anti-proliferative effects against gastric and hepatic carcinoma cell lines have been demonstrated in vitro for this compound class across multiple mushroom species. Its presence in Sparassis contributes to the overall anti-tumor and immunomodulatory profile of the mushroom. Evidence is preclinical.

Tinder PolyporeMushroom

Ergosterol peroxide isolated from F. fomentarius demonstrated anti-proliferative effects against SGC-7091 human gastric carcinoma cells in vitro. Animal studies in HepA tumor-bearing mice showed a 41.42% tumor inhibition rate with concurrent increases in TNF-alpha, IFN-gamma, and IL-2 secretion. The compound constitutes approximately 2.27% of fruiting body sterol content.

Found In 2 Herbs

Cauliflower Mushroom

Mushroom

Tinder Polypore

Mushroom

3D Molecular Structure

Steroid (ergostane-type peroxide)

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Ergosterol peroxide

Steroid (ergostane-type peroxide)Lipid-based molecules that regulate physiological processes

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

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