Ergosterol

Preliminary

Mechanism of Action

Ergosterol inhibits tumor-induced neovascularization by blocking the angiogenic response required for solid tumor growth beyond 1-2 mm diameter. It disrupts vascular endothelial growth factor (VEGF) signaling pathways without exhibiting direct cytotoxicity to tumor cells in vitro, making it an indirect anti-tumor compound with minimal off-target cellular damage. Upon UV exposure, ergosterol converts to vitamin D2 (ergocalciferol), contributing additional immunomodulatory effects through vitamin D receptor (VDR) signaling.

Research Notes

Royal Sun BlazeiMushroom

In vivo studies in Lewis lung carcinoma models demonstrated significant reduction of pulmonary metastatic nodule formation following oral ergosterol supplementation. Anti-angiogenic activity was confirmed in subcutaneous tumor implant models where ergosterol reduced microvessel density surrounding tumors. No direct in vitro cytotoxicity was observed, confirming the anti-angiogenic rather than cytotoxic mechanism.

Found In 1 Herb

Royal Sun Blazei

Mushroom

3D Molecular Structure

Steroid (provitamin D2)

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Ergosterol

Steroid (provitamin D2)Lipid-based molecules that regulate physiological processes

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

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